Indigenous communities experience disproportionality high rates of food insecurity and chronic disease as a byproduct of settler-colonial activities, which included forced relocation to rural reservation lands and degradation of traditional subsistence patterns. Many Indigenous communities have worked to revitalize their local food systems by pursuing food sovereignty, regularly expressed as the right and responsibility of people to have access to healthy and culturally appropriate foods, while defining their own food systems. Food sovereignty is a promising approach for improving health. However, virtually no scientific interventions have incorporated this approach into community based research studies to improve diet and reduce chronic disease risk. This presentation will share the process and outcomes from two randomized control trial studies guided by a food sovereignty framework with Indigenous communities in Oklahoma.