Latin America is one of the most violent and urbanized regions in the world, with large populations living in informal settlements and substantial social and spatial inequalities. Together, these social disadvantages manifest themselves in physical activity inequalities within and across cities. Amid social and gender inequalities, Latin America is also recognized as a major hub for innovation in recreation, urban transport, and mobility policies. These interventions provide culturally competent interventions to promote physical activity among vulnerable populations and women. During this presentation, I will show the evaluation through natural experiments and observational studies that use a mixed-methods approach of programs including the Ciclovías Recretivas, physical activity programs in Parks, and mass transit systems for the public transportation. These programs, out of the health sector have the potential to promote physical activity and impact the well-being of women, children, and older adults and their urban settings in the region of Latin America and could serve as examples for other regions in the world.